Heparin-binding Peptide (trifluoroacetate salt)

Heparin-binding peptide is a synthetic peptide fragment corresponding to residues 1,892-1,899 of the C-terminal heparin-binding domain of fibronectin.1 It induces focal adhesion formation in pre-spread human embryonic fibroblasts (HEFs) when used at concentrations ranging from 1 to 1,000 µg/ml. Heparin-binding peptide inhibits the production of matrix metalloproteinase 1 (MMP-1), MMP-2, and MMP-9 induced by a 40 kDa C-terminal heparin-binding fibronectin fragment (HBFN-f) in isolated human articular cartilage.2 It has been used in peptide surface micropatterning for surface endothelialization.3WARNING This product is not for human or veterinary use.

[1] A WOODS. A synthetic peptide from the COOH-terminal heparin-binding domain of fibronectin promotes focal adhesion formation.[J]. Molecular Biology of the Cell, 1993, 4 6: 605-613. DOI: 10.1091/mbc.4.6.605
[2] TADASHI YASUDA. Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture[J]. Arthritis & Rheumatology, 2003, 48 5: 1271-1280. DOI: 10.1002/art.10951
[3] CORINNE A. HOESLI*. Dynamics of Endothelial Cell Responses to Laminar Shear Stress on Surfaces Functionalized with Fibronectin-Derived Peptides[J]. ACS Biomaterials Science & Engineering, 2018, 4 11: 3779-3791. DOI: 10.1021/acsbiomaterials.8b00774