PG01
PG01 性质
| 沸点 | 704.6±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.217±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：≥10mg/mL |
| 形态 | 粉末 |
| 酸度系数(pKa) | 13.31±0.70(Predicted) |
| 颜色 | 白色至类白色 |
PG01 用途与合成方法
CFTR
PG01 itself does not activate ∆F508-CFTR, produces substantial ∆F508-CFTR Cl - current after the addition of 0.5 and 2 μM Forskolin. PG01 at 100 nM strongly stimulates channel activity with multiple channel openings observed. The apparent K d for PG01 for G551D-CFTR activation is 1 μM, approximately 100-fold better than that of genistein. The potency for activation G1349D-CFTR by PG01 is even better at 40 nM. PG01 produces large currents in both G551D- and G1349D-CFTR expressing cells. The currents are sensitive to CFTRinh-172 and are not seen in nontransfected cells.
Pharmacokinetic analysis of PG01 in rats is done by serial measurements of plasma concentrations after single bolus infusions (5 mg/kg). PG01 pharmacokinetics fitted a two-compartment model with half-times of ＜5 min and 130 min with volume of distribution 4 L. Microsome metabolism studies and rat pharmacokinetic analysis suggests significantly more rapid metabolism of PG01 than SF-03.
PG01 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-103369 | PG01 | 853138-65-5 | 1mg | 1550 |
| 2024-04-30 | HY-103369 | PG01 | 853138-65-5 | 5mg | 4600 |
