AMPICILLIN SODIUM /SULBACTAM SODIUM

Ampicillin sodium/sulbactam sodium in a 2:1 ratio is effective when used parenterally for several types of infections caused by many beta-lactamase-producing bacterial strains of otherwise resistant E. coli, Pasturella spp., Staphylococcus spp., Klebsiella, and Proteus. Other aerobic bacteria commonly susceptible to this combination include Streptococcus, Listeria monocytogenes, Bacillus anthracis, Salmonella, Pasturella, and Acinetobacter. Anaerobic bacterial infections caused by Clostridium, Bacteroides, Fusobacterium, Peptostreptococcus or Propionibacterium may be effectively treated with ampicillin/sulbactam. Type I beta-lactamases that may be associated with Citrobacter, Enterobacter, Serratia and Pseudomonas are not generally inhibited by sulbactam or clavulanic acid. Ampicillin/sulbactam is ineffective against practically all strains of Pseudomonas aeruginosa.
In dogs and cats, ampicillin/sulbactam therapy may be considered when oral amoxicillin/clavulanate treatment is not viable (patient NPO, critically ill) or when large parenteral doses would be desirable (sepsis, pneumonia, other severe infections) for treating susceptible bacterial infections or prophylaxis.
Ampicillin/sulbactam has been used successfully to treat experimentally induced Klebsiella pneumonia in foals.