Valperinol

Valperinol,ZYF Pharm Chemical

Valperinol was prepared in 2 steps:
1). Preparation of 3-piperidinomethyl-4β-hydroxy-8-methoxy-10-methylene- 2,9-dioxatricyclo[4,3,1,03,7]decane: 500 ml of piperidine is added to 250 g of sodium hydrogen carbonate and 190 g of 3-iodomethyl-4β-acetoxy-8- methoxy-10-methylene-2,9-dioxatricyclo[4,3, 1,03,7]decane. The mixture is heated to 150°C in an oil bath during 4 hours under thorough stirring and reflux condenser cooling and then is cooled to room temperature. After adding 7.5 liter of ether, 1 liter of water is added for dissolving the mixture, then 200ml of a 40% sodium hydroxide solution is added and the mixture is shaken. After separation of the etherical phase the aqueous phase is extracted 3 times more with 500 ml of ether each. The united ether extracts are dried over sodium sulfate and clarified with active carbon and filtered by suction, then washed with ether. The filtrate is then evaporated in a rotation evaporator first at 50°C under reduced pressure, which is produced by means of a water jet pump and subsequently at 100°C under vacuum, which is produced by means of an oil pump. Thereby 180 g of oily 3-piperidinomethyl-4β-hydroxy-8- methoxy-10-methylene-2,9-dioxatricyclo[4,3,1,03,7]decane are obtained. These are used without further purifying for the preparation of 3- piperidinomethyl-4β-hydroxy-8-methoxy-10-methyl-2,9- dioxatricyclo[4,3,1,03,7]decane.
2). Preparation of 3-piperidinomethyl-4β-hydroxy-8-methoxy-10-methyl-2,9- dioxatricyclo[4 ,3,1,03,7]decane: A hydrogenation apparatus is flushed with nitrogen for 10 minutes and then flushed with hydrogen for 10 minutes and then is filled with nitrogen. 100 g of moist Raney nickel are washed into the hydrogenation flask by means of methanol and are prehydrogenated under low excess pressure and stirring for about 2 minutes at room temperature. After introducing the solution of 180 g of the substance 3-piperidinomethyl- 4β-hydroxy-8-methoxy-10-methylene-2,9-dioxatricyclo[4,3,1,03,7]decane in 250 ml of methanol into the hydrogenation flask, there is further washed in a mixing solution of sodium hydroxide, which is prepared by dissolving 20 g of sodium hydroxide in a small amount of water, cooling this solution to room temperature and diluting it with methanol to the five fold amount. The mixture is hydrogenated under a low excess of pressure at room temperature for about 30 minutes. After the hydrogen uptake has stopped, the mixture is filtered over theorite through a suction filter which is then washed with methanol (the catalyst must not become dry; danger of fire). 30 ml of acetic acid are added to the filtrate, the solution is evaporated at 60oC., then cooled to room temperature and the residue taken up in ether and worked into a paste with 250 ml of silica gel (particle size 0.2-0.5 mm). After evaporation of the solvent at 50°C, the residue is taken up in a n-hexane and subsequently is evaporated at 60°C. The residue is filtered over a column of 500 g of silica gel (particle size 0.2-0.5 mm) using first 1 liter of n-hexane and then n_x0002_hexane containing 1.5% diethylamine as an eluating solvent. After evaporation of the filtrate at 60°C, 150 g of oily 3-piperidinomethyl-4β- hydroxy-8-methoxy-10-methyl-2,9-dioxatricyclo[4,3,1,03,7]decane (valperinol) are obtained. Empirical formula: C16H27NO4. Molecular weight: 297.399.

Sedative, Antiepileptic, Antiparkinsonian