With stoichiometric amounts of the tetrahydropteridine, the initial rate of tyrosine formation is independent of both the sheep-?liver enzyme and TPNH, a fact that makes it unlikely that either of these components is directly involved in the hydroxylation reaction.A putative cellular function of tetrahydropteridines was investigated in Dictyostelium discoideum Ax2 using a mutant disrupted in the gene encoding sepiapterin reductase.
ChEBI: 5,6,7,8-tetrahydropteridine is a member of pteridines. It has a role as an Escherichia coli metabolite and a cofactor.
