Carbamic acid, cyclopropyl-, 1,1-dimethylethyl ester (9CI)

24424-99-5

765-30-0

132844-48-5

Step 1. Dissolve cyclopropylamine (12.4 g, 252.2 mmol) in dichloromethane (50 mL) at 0°C and cool in an ice water bath. A solution of di-tert-butyl dicarbonate (43.7 g, 200 mmol) in dichloromethane (100 mL) was slowly added dropwise. After the dropwise addition, the reaction mixture was transferred to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the solvent was removed by vacuum evaporation to afford N-Boc-cyclopropylamine (31 g, 99% yield).