Nervonic acid methyl ester

Nervonic acid (24:1n-9) is a very long chain fatty acid produced by elongation of oleic acid (18:1n-9) and derived from erucic acid (22:1n-9) . It is enriched in nervous tissue and is particularly abundant in sphingolipids, such as sphingomyelin in the myelin sheath of nerve fibers. Nervonic acid is poorly produced in demyelinating disorders, including multiple sclerosis and adrenoleukodystrophy, suggesting that dietary supplementation may be beneficial. Nervonic Acid methyl ester is an ester version of the free acid which may be more suitable for the formulation of fatty acid-containing diets and dietary supplements.

Nervonic Acid methyl ester is an ester version ofNervonic Acid (N390110), a fatty acid that can be foundin the white matter of animal brains and in peripheral nervous tissue.Nervonic Acidis one of the major fatty acids in brain sphingolipids, normally accounting for approximately 40% of the total fatty acids in sphingolipids.

ChEBI: Methyl cis-15-tetracosenoate is a fatty acid methyl ester.

[1] DAVID C. TAYLOR. Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use[J]. Plant Biotechnology Journal, 2009, 7 9: 925-938. DOI: 10.1111/j.1467-7652.2009.00454.x
[2] E L HIRVISALO  O R. Composition of human serum sphingomyelins.[J]. Journal of Lipid Research, 1970, 11 1: 54-59.
[3] J.R. SARGENT  R. W  K Coupland. Nervonic acid and demyelinating disease[J]. Medical hypotheses, 1994, 42 4: Pages 237-242. DOI: 10.1016/0306-9877(94)90122-8