Polydeoxyribonucleotide (PDRN), a substance derived from Oncorhynchus mykiss (Salmon trout), is a combination of purine and phosphodiester bonds constituting a pyrimidine nucleotide monomer. The compounds hold a mixture of deoxyribonucleotides polymers with chain lengths ranging between 50 and 2000 bp.
PDRN is able to stimulate VEGF production during pathological conditions of low tissue perfusion. It likely acts through the stimulation of A(2A) receptors.
In a previous study, PDRN accelerated wound healing and improved angiogenesis by increasing the synthesis of vascular endothelial growth factor (VEGF) binding to adenosine A2 receptors. It also improved blood supply and perfusion to the wound. Inadequate perfusion is an important factor in impaired wound healing. In a previous study, PDRN improved angiogenesis in patients with peripheral artery disease, diabetic ulcers, and pressure ulcers. In addition, a PDRN injection represents a safe option for such patients with no side effects.
The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report