长春考酯
长春考酯 性质
| 熔点 | 120-121° |
|---|---|
| 沸点 | 363.6±42.0 °C(Predicted) |
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 8.00±0.40(Predicted) |
长春考酯 用途与合成方法
muscariic acetylcholine receptor
Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [ 3 H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [ 3 H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [ 3 H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [ 3 H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats.
