Cyclopiazonic Acid-13C20

Cyclopiazonic acid-13C20 is intended for use as an internal standard for the quantification of cyclopiazonic acid (Item No. 11326) by GC- or LC-MS. Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 µM).1,2 In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats.3 It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.WARNING This product is not for human or veterinary use.

[1] N W SEIDLER. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum.[J]. The Journal of Biological Chemistry, 1989, 264 30: 17816-17823.
[2] Y UYAMA  M W  Y Imaizumi. Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle.[J]. British Journal of Pharmacology, 1992, 106 1: 208-214. DOI: 10.1111/j.1476-5381.1992.tb14316.x
[3] K. NISHIE  J. W D  R J Cole. Toxicity and neuropharmacology of cyclopiazonic acid[J]. Food and Chemical Toxicology, 1985, 23 9: Pages 831-839. DOI: 10.1016/0278-6915(85)90284-4