HT-2 toxin-13C22 is intended for use as an internal standard for the quantification of HT-2 toxin (Item No. 20431) by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin (Item No. 11444).1,2 Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2 HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50 values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50 value of 56.4 ng/ml.1 It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3 HT-2 toxin has been found in cereal grains and food products.4,5WARNING This product is not for human or veterinary use.
