Pleconaril has been used as a control or reference compound to assess the antiviral activities of the benzothiophene and other heteroaromatic derivatives against hRV-B14, hRV-A21 and hRV-A71.
Picornavirus replication inhibitor. Antiviral.
Pleconaril is a drug, that has antiviral activity.
Pharmaceutical Applications
An oxadiazole active against most enteroviruses and rhinoviruses.
It binds to the hydrophobic pocket of the virus capsid
protein VP1, inducing conformational changes that lead to
altered receptor binding and viral uncoating. Concerns over
safety and efficacy have constrained development of the drug.
Pleconaril is an effective drug against enteroviral infections. It can be used to treat chronic meningoencephalitis caused by echo virus 6.This can block viral replication by blocking the viral uncoating process and viral attachment to host cell receptors.
