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効能
血圧降下薬, 血小板凝集抑制薬, プロスタグランジンI2受容体作動薬
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商品名
ケアロード (東レ); ドルナー (東レ); プロサイリン (科研製薬); ベラサス (科研製薬)
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説明
Beraprost sodium is a new, orally active antithrombotic epoprostenol analog introduced as a treatment for peripheral vascular disease, including Raynaud's syndrome and
Buerger's disease. The antiplatelet activity may be due to its elevation of cyclic AMP
in platelets which is achieved by activating adenylate cyclase in the platelet membrane,
followed by the inhibition ofCa++- influx and thromboxane A2 formation.
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化学的特性
White Solid
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使用
Platelet aggregation inhibitor; stable analog of Prostacyclin. Antithrombotic; vasodilator (peripheral).
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一般的な説明
Beraprost sodium is an orally active prostacyclin analog.
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副作用
Disease-related events had similar incidence in patients receiving beraprost and those receiving placebo. Drug-related adverse events like headache, flushing, jaw pain, and diarrhea were more common in patients treated with beraprost sodium and occurred mostly during the six-week titration period. The incidence was markedly reduced in the maintenance period. Six patients (9%) in the beraprost sodium group and two (3%) in the placebo group withdrew prematurely from the study because of adverse events. No clinically adverse changes in hematologic or biochemical variables were seen in the beraprost sodium group.
