Met-enkephalin-Arg-Phe

Product NameMet-enkephalin-Arg-Phe
CAS73024-95-0
MFC42H56N10O9S
MW877.02
EINECS000-000-0
MOL File73024-95-0.mol

Chemical Properties

Density	1.38±0.1 g/cm3(Predicted)
storage temp.	-15°C
pka	3.49±0.10(Predicted)
Sequence	Tyr-Gly-Gly-Phe-Met-Arg-Phe

Usage And Synthesis

Uses

Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity[1].

Definition

ChEBI: Met-enkephalin-Arg-Phe is an organic molecular entity.

in vivo

Met-Enkephalin-Arg-Phe (10-100 nmol/mouse; i.c.v.; once) shows analgesic activity in mice^[1].

Animal Model:	Male Swiss Webster mice^[1]
Dosage:	10-100 nmol/mouse
Administration:	Intracerebralventricular injection, once
Result:	Produced a dose-related inhibition of the tail-flick response. The effects peaked at 2-4 min and were dissipated by 10 min. The EC₅₀ was 38.5 nmol/mouse.

References

[1] Inturrisi CE, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6-Phe7. Proc Natl Acad Sci U S A. 1980 Sep;77(9):5512-4. DOI:10.1073/pnas.77.9.5512