LY231617 (50 mg/kg; p.o. 30 minutes before occlusion) reduces global ischemic neuronal injury in rats[2].
LY231617 (20 mg/kg; i.v. 30 minutes after occlusion) protects hippocampus and striatum from four-vessel occlusion[2].
| Animal Model: | Male Wistar rats four-vessel occlusion[2] |
| Dosage: | 50 mg/kg |
| Administration: | Oral gavage; 50 mg/kg 30 minutes before occlusion |
| Result: | Significantly protected both the hippocampus and striatum from 30 minutes of four-vessel occlusion.
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| Animal Model: | Male Wistar rats four-vessel occlusion[2] |
| Dosage: | 20 mg/kg |
| Administration: | Intravenous injection ; 20 mg/kg 30 minutes after occlusion |
| Result: | Significantly protected the hippocampus and the striatum when given 30 minutes after the onset of the ischemia at the time of reperfusion.
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