White Powder with Light Yellow Cast
Alexidine Dihydrochloride has antibacterial, antiplaque properties against Streptococcus mutans, Actinomyces ciscosus, and Actinomyces naesludii.
ChEBI: An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.
A mixture of 16 g (0.09 mole) 1,1'-hexamethylene-bis(3-cyanoguanidine) and
20 d (0.12 mole) 2-ethylhexylamine hydrochloride is heated at 150-155°C for
3 hours. The mixture is cooled and the product is dissolved in 75 ml of hot
water. The solution is treated with activated charcoal. 1,1'-Hexamethylene-bis-
(5-(ethylhexyl)biguanide) is recrystalluized from methanol-ether, melting point
220.6-223.4°C.
