FLURBIPROFEN-D3

Flurbiprofen-d₃ is intended for use as an internal standard for the quantification of flurbiprofen (Item Nos. 70250 | 10004207 | 70255) by GC- or LC-MS. Flurbiprofen is a non-selective COX inhibitor (IC₅₀s = 0.04 and 0.51 μM for COX-1 and COX-2, respectively). In vivo, flurbiprofen (0.3-4.8 mg/kg, p.o.) reduces carrageenan-induced hind paw edema and yeast-induced fever in rats. Flurbiprofen reduces plasma fibrinogen levels and arthritic score in a rat model of adjuvant-induced arthritis. It also reduces tumor weight and prostaglandin production and increases survival in a WHT-NC mouse xenograft model when administered at a dose of 5 mg/kg. Formulations containing flurbiprofen have been used to manage pain and inflammation associated with arthritis.

White Solid

An isotopically labelled analog of Flurbiprofen (F598700).

An Isotopically labeled analog of Flurbiprofe

[1] E M GLENN. The pharmacology of 2-(2-fluoro-4-biphenylyl)propionic acid (flurbiprofen). A potent non-steroidal anti-inflammatory drug.[J]. Agents and Actions, 1973, 3 4: 210-216. DOI: 10.1007/bf01968544
[2] A BENNETT. Tumour growth and response to treatment: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen [proceedings].[J]. British Journal of Pharmacology, 1978, 63 2: 356P-357P.