Stachybotrysin B is a fungal metabolite originally isolated from
S. chartarum and has antiviral and anticancer activities.
1,2 It has antiviral activity against HIV in SupT1 cells (IC
50 = 19.2 μM).
1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC
50s = 21.72, 39.63, and 18.5 μM, respectively).
2
1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum J. Nat. Prod. 80(6),1819-1826(2017).
2. Ma, X.-h., Zheng, W.-m., Sun, K.-h., et al. Two new phenylspirodrimanes from the deep-sea derived fungus Stachybotrys sp. MCCC 3A00409 Nat. Prod. Res. 33(3),386-392(2018).
