Histone H3 (21-44)-GK-biotin amide (trifluoroacetate salt)

Histone H3 (21-44)-GK-biotin is a peptide fragment of histone H3 that corresponds to amino acid residues 22-45 of the human histone H3.3 sequence and is biotinylated via a C-terminal GK linker. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis.1 Histone H3 (21-44) also contains lysine residues at positions 23, 27, and 36 that are subject to methylation and acetylation, all of which have a role in the regulation of gene expression, and a serine residue at position 28 that is subject to phosphorylation during mitosis.2,3,1WARNING This product is not for human or veterinary use.

[1] SANDRA B HAKE. Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2005: 6344-6349. DOI: 10.1073/pnas.0502413102
[2] SUKESH R BHAUMIK  Ali S  Edwin Smith. Covalent modifications of histones during development and disease pathogenesis[J]. Nature Structural & Molecular Biology, 2007, 14 11: 1008-1016. DOI: 10.1038/nsmb1337
[3] BENJAMIN A GARCIA. Organismal differences in post-translational modifications in histones H3 and H4.[J]. The Journal of Biological Chemistry, 2007, 282 10: 7641-7655. DOI: 10.1074/jbc.m607900200