Mindbomb homolog 1 is an E3 ligase that facilitates the ubiquitination and the subsequent endocytosis of the Notch ligands, Delta and Jagged. MIB1 appears to promote the ubiquitination and degradation of death-associated protein kinase in vitro. Expression of MIB1 is seen in both adult and embryonic murine tissues. Recently, MIB1 was reported to regulate the extrinsic cell death pathway by binding to cellular FLICE-like inhibitory proteins, which reduces the interaction of caspase-8 with cFLIP and leads to cell death. MIB1 is also involved in T and marginal zone B cell development in the lymphopoietic niches.
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