1,3,4,5-Tetrahydro-pyrano[4,3-b]indole

The synthesis method of 1,3,4,5-TETRAHYDRO-PYRANO[4,3-B]INDOLE is as follows: Bubble argon to a suspension of 2-chloroaniline (208.1 mg, 1.63 mmol), tetrahydropyran-4-one (477.3 mg, 4.77 mmol), acetic acid (0.14 mL, 2.45 mmol) and magnesium sulfate (116.7 mg, 0.97 mmol) in dimethylacetamide (3.0 mL) for 10 minutes; Add tripotassium phosphate (437.7 mg, 2.06 mmol) and [Pd (tBu3P)2] (84.1 mg, 0.16 mmol); Bubble argon through the mixture for an additional 5 minutes; Heat the reaction mixture for 2 hours at 140 °C in a sealed tube; Cool the mixture to room temperature and filter; Add water (10 mL) to the filtrate and extract with ethyl acetate (3 x 20 mL); Dry the combined organic layers over magnesium sulfate, filter and concentrate in vacuo; Purify by flash chromatography (n-hexane/EtOAc 80/20).

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