Delparantag (PMX-60056; 0.5 mg/kg, 1.0 mg/kg, or 2.0 mg/kg; intravenous injection; once; male Sprague-Dawley rats) treatment neutralizes the antithrombotic, anticoagulant, and bleeding effects of heparins as effectively as protamine sulfate and may be slightly more efficacious against LMWHs[2].
Plasma half-life elimination of Delparantag is between 3 and 5 min[1].
| Animal Model: | Male Sprague-Dawley rats (250-275 g) injected with UFH or LMWH (2.0 mg/kg)[2] |
| Dosage: | 0.5 mg/kg, 1.0 mg/kg, or 2.0 mg/kg |
| Administration: | Intravenous injection; once |
| Result: | Neutralizes the antithrombotic, anticoagulant, and bleeding effects of heparins as effectively as protamine sulfate and may be slightly more efficacious against LMWHs.
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