Imidazo[1,2-a]pyrimidine

109-12-6

2032-35-1

274-95-3

In a 250-mL three-necked round-bottomed flask, 2-aminopyrimidine (5 g, 0.052 mol), bromoacetaldehyde diethyl acetal (20.7 g, 0.104 mol), 48% aqueous hydrobromic acid (5 mL), and ethanol (50 mL) were added sequentially. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was cooled to room temperature. Subsequently, the reaction mixture was adsorbed onto silica gel and purified by column chromatography (eluent: dichloromethane/methanol), resulting in 5 g of imidazo[1,2-a]pyrimidine in about XX% yield.