3-keto Sphinganine (d6:0) (hydrochloride)

3-keto Sphinganine (d6:0) is a short-chain analog of the typical C18 chain-length 3-keto sphinganine (d18:0) . 3-keto Sphinganine (d18:0) is a lyso-sphingolipid formed by the condensation of L-serine and palmitoyl-CoA by serine palmitoyl transferase (SPT). Vitamin K deficiency inactivates SPT resulting in a decrease in the production of 3-keto sphinganine and other sphingolipids.¹

3-Keto sphinganine (d6:0) (3-Keto-C6-dihydrosphingosine) hydrochloride, an ester product, is a short-chain analog of 3-keto sphinganine. 3-keto sphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells[1].

1. Batheja, A.D., Uhlinger, D.J., Carton, J.M., et al. Characterization of serine palmitoyltransferase in normal human tissues J. Histochem. Cytochem. 51(5),687-696(2003).