ChemicalBook Product Catalog Biochemical Engineering Saccharides Oligosaccharides STACHYOSE

STACHYOSE

Chemical Properties

Melting point	110 °C(dec.)
storage temp.	-20°C
Water Solubility	Soluble in water
solubility	DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
form	Liquid
color	Clear colorless to yellow to pale brown, may darken during storage
biological source	plant (Stachys tuberifera)
optical activity	[α]24/D +133°, c = 4 in H2O
BRN	5710666
Stability	Hygroscopic
InChIKey	YDBMRUQRXAFOAH-KTDNCYJLSA-N
SMILES	O.OC[C@H]1O[C@H](OC[C@H]2O[C@H](OC[C@H]3O[C@H](O[C@]4(CO)O[C@H](CO)[C@@H](O)[C@@H]4O)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@H]1O

Animal Model:	DSS (HY-116282C)-induced ulcerative colitis C57BL/6J mouse model^[2]
Dosage:	200, 400, 600 mg/kg
Administration:	Oral gavage (p.o.), once daily for 3 weeks
Result:	Significantly alleviated colitis symptoms in DSS-induced colitis mice, including reducing weight loss, lowering disease activity index (DAI), and increasing colon length, while restoring colonic epithelial barrier integrity. Dose-dependently upregulated mRNA expression of ZO-1, Claudin-1, and Occludin, reduced IL-17, TNF-α, IL-1β, and IL-6 expression, and increased IL-10 levels.