(S)-3,5-Dihydroxyphenylglycine

(S)-3,5-Dihydroxylphenylglycine is a potent agonist of group I metabotropic glutamate receptors mGluR1 and mGluR5. (S)-3,5-Dihydroxylphenylglycine have been utilized for the treatment of neuronal injury and cognitive enhancement.

(S)-3,5-Dihydroxyphenylglycine hydrate has been used:

• as mGluR1/5agonist for metabotropic glutamate receptor 1 (mGluR1/5) activation in synaptoneurosomal preparations
• in ACSF for DHPG stimulation
• to inject into basolateral amygdala to study its effect on memory expression

ChEBI: (S)-3,5-dihydroxyphenylglycine is a glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups. It is a member of resorcinols and a non-proteinogenic L-alpha-amino acid. It is functionally related to a L-alpha-phenylglycine. It is a tautomer of a (S)-3,5-dihydroxyphenylglycine zwitterion.

Selective group I mGlu receptor agonist. Also available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ .

(S)-3,5-Dihydroxyphenylglycine hydrate is a group I metabotropic glutamate receptor agonist.

-20°C (desiccate). Protect from light.