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CHROMOMYCIN A3

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CHROMOMYCIN A3 Basic information
CHROMOMYCIN A3 Chemical Properties
  • Melting point:185℃
  • alpha D23 -57° (ethanol)
  • Boiling point:780.13°C (rough estimate)
  • Density 1.1451 (rough estimate)
  • refractive index 1.6500 (estimate)
  • storage temp. 2-8°C
  • solubility Soluble in ethanol, DMSO, and ethyl acetate (10 mg/ml).
  • form Yellow solid
  • pka4.54±0.60(Predicted)
  • Merck 13,2258
Safety Information
  • Hazard Codes T+,T
  • Risk Statements 61-28
  • Safety Statements 53-28-36/37/39-45
  • RIDADR UN 3462 6.1/PG 1
  • WGK Germany 3
  • RTECS GB7875000
  • 3-8-10
  • HazardClass 6.1(a)
  • PackingGroup I
  • HS Code 29419090
  • ToxicityExcitation max: ~445 nm. Emission max: ~575 nm. Sol in ethanol, ethyl acetate, DMSO, methanol. LD50 in mice (mg/kg): 1.85 i.v. (Slavik, Carter).
MSDS
CHROMOMYCIN A3 Usage And Synthesis
  • Chemical PropertiesYellow powder
  • UsesChromomycin A3 is the major component of the chromomycin complex of the aureolic acid class, isolated from several Streptomyces species, and first reported in 1960. Chromomycin A3 exhibits a broad biological profile as an antibacterial, antifungal and antitumour agent. It binds reversibly to GC-specific DNA ligand in the minor groove which inhibits transcription, DNA gyrase and topoisomerase II activity. The intense UV spectrum and strong fluorescence makes chromomycin a useful stain for DNA.
  • UsesFluorescent DNA stain in flow cytometry and karyotype analysis of chromosomes.
  • Purification MethodsDissolve the antibiotic (10g) in EtOAc and add to a column of Silica Gel (Merck 0.05-0.2microns, 4x70cm) in EtOAc containing 1% oxalic acid. Elute with EtOAc+1% oxalic acid and check fractions by TLC. Pool fractions, wash with H2O thoroughly, dry and evaporate. Recrystallise the residue from EtOAc. The heptaacetate has m 214o, [] D -20o (c 1, EtOH). [Miyamoto et al. Tetrahedron 23 421 1967, Harada et al. J Am Chem Soc 91 5896 1969, Beilstein 17/5 V 673.]
CHROMOMYCIN A3(7059-24-7)Related Product Information
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