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Prostaglandin B₂ (PGB₂-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGB₂ by GC- or LC-mass spectrometry. PGB₂ is a non-enzymatic dehydration product resulting from the treatment of PGE₂ or PGA₂ with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 mg/kg).¹

1. Liu, F., Orr, J.A., and Wu, J.Y. Prostaglandin B₂-induced pulmonary hypertension is mediated by TXA₂/PGH₂ receptor stimulation Am. J. Physiol. 1040,L602-L607(1994).