Description
Prostaglandin B
2 (PGB
2-
d
4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of PGB
2 by GC-
or LC-
mass spectrometry. PGB
2 is a non-
enzymatic dehydration product resulting from the treatment of PGE
2 or PGA
2 with strong base. It has weak agonist activity on TP receptors and can increase pulmonary blood pressure in the rabbit at relatively high doses (5 mg/kg).
1
References
1. Liu, F., Orr, J.A., and Wu, J.Y.
Prostaglandin B2-induced pulmonary hypertension is mediated by TXA2/PGH2 receptor stimulation Am. J. Physiol. 1040,L602-L607(1994).
