DEA

Product NameDEA
CAS150314-35-5
MFC24H41NO2
MW375.59
EINECS
MOL File150314-35-5.mol

Chemical Properties

Boiling point	544.5±50.0 °C(Predicted)
Density	0.932±0.06 g/cm3(Predicted)
storage temp.	Desiccate at -20°C
solubility	DMF: 10 mg/ml; DMSO: 30 mg/ml; Ethanol: 100 mg/ml; Ethanol:PBS (1:2): 8 mg/ml; PBS (pH 7.2): <100 μg/ml
pka	14.49±0.10(Predicted)

Usage And Synthesis

Description

Docosatetraenoyl ethanolamide (DEA) is an endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA. DEA acts on CB₁ receptors with potency and efficacy similar to that of AEA. However, its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated.

Uses

(7Z,10Z,13Z,16Z)-N-(2-Hydroxyethyl)-7,10,13,16-docosatetraenamide is an endocannabinoid and an analog of anandamide, which is an endogenous cannabinoid and TRPV1 receptor agonist.

Definition

ChEBI: 7,10,13,16-Docosatetraenoylethanolamine is a N-acylethanolamine 22:4.

Biological Activity

Potent endocannabinoid ( anandamide analog) that activates CB 1 receptors in microglia and binds to rat synaptosomal membranes (K I = 34.4 nM). Cannabimimetic in vivo .