M-3M3FBS

m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3

m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation.

m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis¹. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells².

ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.

Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types.

First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms).

Store at RT

[1] YOE-SIK BAE. Identification of a compound that directly stimulates phospholipase C activity.[J]. Molecular Pharmacology, 2003, 63 5: 1043-1050. DOI:10.1124/mol.63.5.1043
[2] YOUL-NAM LEE . The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis[J]. Cancer letters, 2005, 222 2: Pages 227-235. DOI:10.1016/j.canlet.2004.09.017
[3] JELENA KRJUKOVA. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation[J]. British Journal of Pharmacology, 2009, 143 1: 3-7. DOI:10.1038/sj.bjp.0705911