Syringaresinol

Syringaresinol is a lignan that can be extracted from the dragon's blood of the Dracaena tree. Syringaresinol increases NO production by increasing the phosphorylation and dimerization of endothelial NO synthase, exerting a vasodilatory effect. Syringaresinol also inhibits the NF-κB pathway, exerting anti-inflammatory activity and inhibiting arthritis[1][2][3].

ChEBI: Syringaresinol is a lignan that is 7,9':7',9-diepoxylignane substituted by hydroxy groups at positions 4 and 4' and methoxy groups at positions 3, 3', 5 and 5' respectively. It has a role as a plant metabolite. It is a lignan, a polyphenol, an aromatic ether, a furofuran and a polyether.

[1] Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982. DOI:10.1016/j.intimp.2023.109982
[2] YingLUO, et al. Chemical Constituents from Dragon's Blood of Dracaena cambodiana. Chinese Journal of Natural Medicines, Volume 9, Issue 2, March 2011, Pages 112-114.
[3] Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201. DOI:10.3858/emm.2012.44.3.014