RAD51 INHIBITOR B02
RAD51 INHIBITOR B02 性质
| 熔点 | 174-175o C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 粉末 |
| 颜色 | 淡黄色至深黄色 |
| 稳定性 | 吸湿性 |
| InChI | 1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+ |
| InChIKey | GEKDQXSPTHHANP-OUKQBFOZSA-N |
| SMILES | O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4 |
RAD51 INHIBITOR B02 用途与合成方法
IC50: 27.4 μM (hRAD51)
RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC 50 =27.4 μM), but not its E. coli homologue RecA (IC 50 >250 μM). The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231.
B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo . B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth.
RAD51 INHIBITOR B02 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-101462 | 1290541-46-6 | 1 mg | 308 | |
| 2026-09-15 | HY-101462 | RAD51 INHIBITOR B02 | 1290541-46-6 | 5mg | 770 |
