FIIN-1 is a fibroblast growth factor receptor (FGFR) Irreversible Inhibitor 1 (1).The fibroblast growth factor receptor tyrosine kinases are promising therapeutic targets in a number of cancers and FIIN-1 is a useful probe of FGFR-dependent cellular phenomena and may assist in the development of therapeutically relevant irreversible inhibitors, particularly for wild-type and drug-resistant forms of FGFR kinases.
FIIN-1 is a fibroblast growth factor receptor (FGFR) Irreversible Inhibitor 1.The fibroblast growth factor receptor tyrosine kinases are promising therapeutic targets in a number of cancers and FIIN-1 is a useful probe of FGFR-dependent cellular phenomena and may assist in the development of therapeutically relevant irreversible inhibitors, particularly for wild-type and drug-resistant forms of FGFR kinases.
FGFR1: 2.8 nM (Kd); FGFR2: 6.9 nM (Kd); FGFR3: 5.4 nM (Kd); FGFR4: 120 nM (Kd); FGFR1: 9.2 nM (IC50); FGFR2: 6.2 nM (IC50); FGFR3: 11.9 nM (IC50); FGFR4: 189 nM (IC50)
