PAF C-18-d4

PAF C-18-d4 contains four deuterium atoms at the 9, 9', 10, and 10' positions. It is intended for use as an internal standard for the quantification of PAF C-18 by GC- or LC-mass spectrometry. PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages.2 PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages.3 Pathological processes involving PAF include necrotizing enterocolitis,4 inflammation, asthma, and allergy.5WARNING This product is not for human or veterinary use.

[1] K DEGUCHI  A D  S Murashima. [Platelet activating factor].[J]. Nihon rinsho. Japanese journal of clinical medicine, 1987, 45 5: 1115-1126.
[2] A G STEWART  G G. Structure-activity relationships for platelet-activating factor (PAF) and analogues reveal differences between PAF receptors on platelets and macrophages.[J]. Journal of lipid mediators, 1991, 4 3: 299-308.
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[4] HAO WANG. Platelet-Activating Factor (PAF) Up-Regulates Plasma and Tissue PAF-Acetylhydrolase Activity in the Rat: Effect of Cycloheximide[J]. Pediatric Research, 1997, 42 5: 597-603. DOI: 10.1203/00006450-199711000-00008
[5] A STURK. The synthesis, catabolism, and pathophysiological role of platelet-activating factor.[J]. Advances in lipid research, 1989, 23: 219-276. DOI: 10.1016/b978-0-12-024923-7.50010-8