PAF C-16-d4 contains four deuterium atoms at the 7, 7'', 8, and 8'' positions of the hexadecyl moiety. It is intended for use as an internal standard for the quantification of PAF C-16 by GC- or LC-mass spectrometry. PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and ''de novo'' pathways. It is a potent mediator of neutrophil migration, the production of reactive oxygen species, and IL-6 in human macrophages. It is a more potent mediator of platelet aggregation than PAF C-18. Pathological processes involving PAF include necrotizing enterocolitis, inflammation, asthma, and allergy.
