15-deoxy-Δ12,14-Prostaglandin J2-biotin

15-deoxy-Δ12,14-Prostaglandin J2 (15-deoxy-Δ12,14-PGJ2; Item No. 18570) is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. 15-deoxy-Δ12,14-PGJ2-biotin is an affinity probe which allows 15-deoxy-Δ12,14-PGJ2 to be detected through an interaction with the biotin ligand. 15-deoxy-Δ12,14-PGJ2-biotin was designed to allow 15-deoxy-Δ12,14-PGJ2 to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.WARNING This product is not for human or veterinary use.

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[2] Y KIKUCHI. Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells.[J]. Cancer and Metastasis Reviews, 1994, 13 3-4: 309-315. DOI: 10.1007/bf00666101
[3] E. MUELLER. Genetic Analysis of Adipogenesis through Peroxisome Proliferator-activated Receptor γ Isoforms*[J]. The Journal of Biological Chemistry, 2002, 55 1: 41925-41930. DOI: 10.1074/jbc.m206950200
[4] ARAVINDT. REDDY. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2[J]. ACS Chemical Biology, 2018, 13 12: 3269-3278. DOI: 10.1021/acschembio.8b00584
[5] BEATRIZ DÍEZ-DACAL. Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.[J]. Cancer research, 2011: 4161-4171. DOI: 10.1158/0008-5472.can-10-3816