15-deoxy-Δ12,14-Prostaglandin J2-d9

15-deoxy-Δ12,14-Prostaglandin J2-d9 (15-deoxy-Δ12,14-PGJ2-d9) is intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 (Item No. 18570 | 18570.1) by GC- or LC-MS. 15-deoxy-Δ12,14-PGJ2 is formed from PGD2 (Item No. 12010) by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-Δ12,14-PGJ2 is more potent than PGD2, Δ12-PGJ2 (Item No. 18550), and PGJ2 (Item No. 18500) in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1WARNING This product is not for human or veterinary use.

[1] S A KLIEWER. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation.[J]. Cell, 1995, 83 5: 813-819. DOI: 10.1016/0092-8674(95)90194-9
[2] B M FORMAN. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma.[J]. Cell, 1995, 83 5: 803-812. DOI: 10.1016/0092-8674(95)90193-0