SJG 136
SJG 136 性质
| 沸点 | 805.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.36±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 二甲基亚砜：≥100mg/mL（179.66mM） |
| 酸度系数(pKa) | 3.88±0.20(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色至黄色 |
SJG 136 用途与合成方法
XL50: 45 nM (pBR322 DNA)
SJG-136 (dimer 5) is a DNA cross-linking agent, with an XL 50 (concentration of agent required for 50% cross-linking of pBR322 DNA) of 45 nM for pBR322 DNA. SJG-136 is cytotoxic to ovarian cell lines, such as A2780 (IC 50 , 22.5 pM), A2780cisR (IC 50 , 24 pM), CH1 (IC 50 , 0.12 nM), CH1cisR (IC 50 , 0.6 nM), and SKOV-3 (IC 50 , 9.1 nM). SJG-136 (SG2000) also reduces the viability of a panel of canine cancer cells, with GI 50 values ranging from 0.33 - >100 nM after a 1 h exposure, and <0.03 - 17.33 nM following continuous exposure.
SJG-136 shows more potent antitumor effect against CMeC-1 tumour at 0.30 mg/kg than 0.15 mg/kg either as a single dose or administered once a week for three weeks via dosed intravenously in mice. SJG-136-induced H2AX phosphorylation shows good correspondence, but less sensitivity, than measurement of foci.
SJG 136 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024-04-30 | HY-14573 | SJG 136 | 232931-57-6 | 1 mg | 2800 |
| 2024-04-30 | HY-14573 | SJG 136 | 232931-57-6 | 5mg | 4900 |
