(+/-)-5,6-Epoxyeicosa-8z,11z,14z-trienoic acid methyl ester

(±)5(6)-EET (Item No. 50211) is biosynthesized in rat and rabbit liver microsomes by CYP450.1,2 In neuroendocrine cells, such as the anterior pituitary and pancreatic islet, (±)5(6)-EET has been implicated in the mobilization of Ca2+ and hormone secretion.3,4 Since (±)5(6)-EET is highly unstable, (±)5(6)-EET methyl ester is used for bulk storage and small amounts converted to the free acid just before use.WARNING This product is not for human or veterinary use.

[1] N. CHACOS . Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acid[J]. Biochemical and biophysical research communications, 1982, 104 3: Pages 916-922. DOI: 10.1016/0006-291x(82)91336-5
[2] E. OLIW J O F Guengerich. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates.[J]. The Journal of Biological Chemistry, 1982, 109 1: 3771-3781. DOI: 10.1016/s0021-9258(18)34848-8
[3] G. SNYDER . 5,6-epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells[J]. Biochemical and biophysical research communications, 1986, 139 3: Pages 1188-1194. DOI: 10.1016/s0006-291x(86)80303-5
[4] J.R. FALCK . Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets[J]. Biochemical and biophysical research communications, 1983, 114 2: Pages 743-749. DOI: 10.1016/0006-291x(83)90843-4