Oral administration of Zanapezil (TAK-147; 3 mg/kg) free base significantly accelerated the turnover rates of dopamine, noradrenaline and serotonin in the rat brain. Oral administration of Zanapezil free base at doses ranging from 1 to 10 mg/kg induces a statistically significant and dose-dependent decrease in AChE activity in the cerebral cortex in ex vivo experiments[1].
Zanapezil (TAK-147; 5 and 10 mg/kg) free base significantly increases ACh level in the ventral hippocampus (VH) for 120 min[2].
| Animal Model: | Male Wistar rats 7 weeks in age (230-240 g)[2] |
| Dosage: | 5 and 10 mg/kg |
| Administration: | Oral administration |
| Result: | Increased acetylcholine (ACh) level in the VH for 120 min. |
