8-(4-Chlorophenylthio)guanosine 3',5'-cyclic monophosphothioate, RP-isomer triethylammonium salt

Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (Ki=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets[1].

Cell permeable: yes', 'Primary Target
PKG1α', 'Product does not compete with ATP.', 'Reversible: no

[1] E Butt, et al. (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. European Journal of Pharmacology: Molecular Pharmacology 269.2 (1994): 265-268. DOI:10.1016/0922-4106(94)90095-7