Ethyl 8-chloro-6-hydroxyoctanoate is used in biological study for the enzymic resolution of chiral chlorohydrin precursor for (R)-α-lipoic acid synthesis via lipase catalyzed enantioselective transacylation with vinyl acetate.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 416, 1955 DOI:10.1021/ja01607a057
