((R,R)-2-AMINO-1,2-DIPHENYLETHYL)[(4-TOLYL)SULFONYL]AMIDO](P-CYMENE)RUTHENIUM(II)CHLORIDE

This catalyst has shown to effect highly enantioselective hydrogenation of functionalized ketones where the substituents are dialkylamino, hydoxy, siloxy, carbonyl, ester, amide or thioester.

Orange to brown powder

Phosphine cationic ruthenium catalysts used for enantioselective hydrogenation of:

• Quinolines
• N-Alkyl ketimines
• Antitumor and antiproliferative derivatives of natural products isolated from bacteria
• Hydroxy arylaldehydes via Rap-Stoermer-enantioselective transfer hydrogenation

Catalyst with improved performance modified via microenvironment engineering of nanocages

RuCl(p-cymene)[(R,R)-Ts-DPEN] is a chiral diamine ligand complexed with ruthenium.

In a dry reactor, ruthenium chloride catalyst ( 167 mg , 0.273 mmol), mono-p-toluenesulfonic acid diamine ( 0.546 mmol), and triethylamine ( 155 L , 1.11 mmol) were dissolved in dry isopropanol ( 5.5 m L ), and then the resulting reaction mixture was heated to 80 C and reacted with stirring at 80 C for 75 minutes. At the end of the reaction the resulting reaction solution was cooled to room temperature. The resulting solution was concentrated to half its volume under reduced pressure, and then 1.5 mL of deionized water was added to the resulting reaction mixture to precipitate the catalyst. The resulting precipitate was collected by filtration and dried under vacuum to afford the target catalyst (R,R)-N-(p-toluenesulfonyl)-1,2-diphenylethane diamine (p-isopropylphenyl)ruthenium chloride.