(S) -3-amino-3 -(4-chlorophenyl)propan-1-ol can be synthesized through chemical catalysis or biological transaminase catalysis.
(1) Chemical synthesis method: Using chloroacetonitrile and methanol as the starting substrates, HCl gas is introduced during the reaction process to obtain iminochloroethyl alkyl ether hydrochloride. Subsequently, Amino urea hydrochloride is added to obtain (S) -3-amino-3 -(4-chlorophenyl)propan-1-ol. Alternatively, (S) -3-amino-3 -(4-chlorophenyl) -propan-1-OL can be obtained through catalytic reduction using the prepared (S) -3-amino-3 -(4-chlorophenyl) -propionic acid as the precursor.
(2) Biosynthesis method: Using 1-(4-chlorophenyl) -3-hydroxyacetone as the substrate and transaminase (SEQ ID NO. 1-6) and its mutants as catalysts, (S) -3-amino-3 -(4-chlorophenyl)propan-1-ol is prepared through transamination reaction.
