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ketazolam

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ketazolam Basic information
ketazolam Chemical Properties
  • Melting point:182-183.5° (sinters at 170°)
  • Boiling point:645.0±55.0 °C(Predicted)
  • Density 1.41±0.1 g/cm3(Predicted)
  • pka-0.84±0.60(Predicted)
Safety Information
  • RIDADR 3249
  • HazardClass 6.1(b)
  • PackingGroup III
ketazolam Usage And Synthesis
  • OriginatorAnxon,Beecham,UK,1980
  • UsesA psychotropic benzodiazepine derivative with hypnotic and anxiolytic properties. Controlled Substance.
  • Manufacturing ProcessA solution of 0.7 g of 2-(2-amino-N-methylacetamido)-5-chlorobenzophenone in 10 ml of a 50% solution (by weight) of diketene in acetone is refluxed for 3 hours and then evaporated to give a brown oil. The oil is chromatographed on 200 g of silica gel using a 1:1 (by volume) mixture of ethyl acetate cyclohexane; 25 ml fractions are collected. Fractions 11-14 are combined, mixed with chloroform, evaporated and triturated with ether to give 0.337 g of 11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d] [1.4] benzodiazepine-4,7(6H)-dione as a pale yellow solid, MP 174°C to 176°C.
  • Therapeutic Function Antianxiety
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