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Etifoxine

Basic information Safety Related Supplier
Etifoxine Basic information
Etifoxine Chemical Properties
  • Melting point:90-92℃
  • Boiling point:421.2±55.0 °C(Predicted)
  • Density 1.1716 (rough estimate)
  • refractive index 1.5800 (estimate)
  • pka4.89±0.40(Predicted)
Safety Information
  • ToxicityLD50 orally in mice: 12 g/kg (Hoffmann)
Etifoxine Usage And Synthesis
  • OriginatorCircupon,Troponwerke,W. Germany
  • Manufacturing Process30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
    3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
  • Therapeutic FunctionTranquilizer
Etifoxine(21715-46-8)Related Product Information
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