2-Pyridinesulfonyl Chloride is used for preparation of pyridinesulfonyl derivatives.
Pyridine-2-sulfonyl Chloride is generated as needed from 2,2′-Dipyridyl Disulfide. Treatment of 2,2′- dipyridyl disulfide in petroleum ether or dichloromethane with either Chlorine or Bromine at 20 °C results in 2- pyridinesulfenyl halide generation after 1-2 h. Isolation through evaporation of solvent provides a yellow powder with a pungent odor.
Pyridine-2-sulfonyl Chloride demonstrates instability, especially in the presence of moisture. Although the isolated powder may tolerate short-term storage in a well sealed vial or ampule, most work involving these reagents has utilized freshly prepared material.
