Seltorexant hydrochloride

Chemical Properties

form	Solid
color	Off-white to light yellow

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Animal Model:	Male Sprague-Dawley rats (350-450 g)^[1]
Dosage:	30 mg/kg
Administration:	p.o.; per day for 7 days
Result:	The reduced sleep onset (non–rapid eye movement (NREM) latency) and the increased NREM sleep duration were maintained upon 7-day repeated dosing with JNJ-42847922. The prolongation of NREM sleep time was due to a significant increase in NREM bout duration throughout the treatment period assessed on D1 and D7. Rapid eye movement (REM) sleep was only marginally affected on D4 of treatment, resulting in a small but significant reduction in REM sleep latency and an increase in REM sleep duration.