苯噻啶苹果酸盐
苯噻啶苹果酸盐 性质
| 熔点 | 185-186° (dec) |
|---|---|
| 储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
| 溶解度 | 酸水溶液（微溶，加热）、DMSO（微溶）、甲醇（微溶） |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 稳定性 | 吸湿性 |
| 主要应用 | 药物 药物小分子 |
| InChI | 1S/C19H21NS.C4H6O5/c1-20-11-8-15(9-12-20)19-16-5-3-2-4-14(16)6-7-18-17(19)10-13-21-18;5-2(4(8)9)1-3(6)7/h2-5,10,13H,6-9,11-12H2,1H3;2,5H,1H2,(H,6,7)(H,8,9) |
| InChIKey | IWAWCPZVTXCFKD-UHFFFAOYSA-N |
| SMILES | [s]1c2c(cc1)C(=C4CCN(CC4)C)c3c(cccc3)CC2.OC(CC(=O)O)C(=O)O |
苯噻啶苹果酸盐 用途与合成方法
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5-HT 2A Receptor
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5-HT 1C Receptor
|
Pizotifen malate (BC-105 malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Pizotifen is an antidepresent 5-HT 2A receptor antagonist and has the capacity to inhibit serotonin-enhanced ADP-induced platelet aggregation.
The weights of the fetuses are significantly reduced by all administered doses of Pipethiadene and Pizotifen malate (BC-105 malate) ; the weights of the placentas are significantly reduced after 0.6 and 1.2 mg/kg Pipethiadene and only after the middle dose of Pizotifen malate. The means of the implantations, live, dead fetuses, resorptions and the occurrence of external, skeletal and visceral anomalies do not differ from the control group. The number of chromosome aberrations in the bone marrow cells of treated mice does not differ significantly from the negative control group. The micronucleus test reveals no elevation in the frequency of micronuclei as compared to the control group. After the two higher doses of both Pipethiadene and Pizotifen maleate, the mitotic indices are lower than in the control group.
苯噻啶苹果酸盐 价格(试剂级)
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026-09-15 | HY-B0115A | 苯噻啶苹果酸盐 | 5189-11-7 | 100 mg | 200 |
| 2026-09-15 | HY-B0115A | 苯噻啶苹果酸盐 | 5189-11-7 | 10 mM * 1 mL in DMSO | 220 |
